Alzheimer’s disease (AD) is a slowly progressive irreversible neurodegenerative disorder that manifests as microstructural changes in the sub-anatomic regions of the brain. These changes are often analysed using MR imaging. However, initial stage assessment of Early Mild Cognitive Impairment (EMCI) is still a complex research issue. In this work, EMCI associated with progress of AD is comprehensively analysed using structural and volumetric texture analyses. A method has been developed to differentiate EMCI from other AD conditions using subtle variations in the MR images. In this presentation, the methodology, results, significant conclusions and contributions are discussed.