Cancer, cardiovascular diseases, and neurological disorders cause serious health problems worldwide. Emerging research reveals complex genetic links between these seemingly distinct diseases, suggesting shared molecular mechanisms. Within cancer cells, specific genetic mutations known as "hotspots" play a crucial role in tumour development and contribute to the onset of other diseases. Identifying these hotspots is vital for targeted drug development. In this seminar, I will address the complex relationship among cancer, cardiovascular, and neurological disorders, highlighting their shared genetic roots. The crucial role of hotspot mutations and the importance of protein residue-residue interaction networks for understanding disease mechanisms will be explored, along with the limitations of existing computational hotspot prediction methods. Further, novel residue-residue interaction networks constructed for cancer-specific proteins and statistical analysis of their features will be discussed. Preliminary findings offer insights into the network's potential to deepen our understanding of diseases and guide future therapeutic approaches.