In the 21st century, we are dealing with several severe environmental issues like pollution, global warming and fast depletion of natural resources. These are directly linked to the global energy consumption. Out of many things happening in our daily life, friction (20%) and wear (3%) are the major contributors to the global energy consumption accounting to around 23%. Whether it be cars, household appliances, industrial machinery, pumps etc., each one of them experience some kind of friction and wear when metal parts inside them slide against each other. This leads to energy losses. Science behind interacting surfaces, i.e., tribology plays a significant role in our life. Application of lubricants in between the interacting surfaces helps in reducing the friction and wear and thereby reducing the energy losses. Nano-lubricants have proved to be the next generation alternatives to conventional lubricants like engine oil, mineral oil, vegetable oil etc. due to advancement in lubricant technology. Several studies have been carried out in literature with different additives such as Graphite, Graphene, Carbon spheres, Carbon nanotubes, Metals, Metal oxides, MoS2, Boron, WS2 etc. TiO2 is a widely used novel lubricant additive due to its high hardness, high fracture toughness and thermo-chemical stability. In this work, surface functionalized TiO2 nano-additives are synthesized and then dispersed in commercial engine oil. Tribological properties of these nanolubricants like friction and wear are investigated in four ball tester as per ASTM standards. The results show improved tribological performance and enhanced lubrication behavior by significant reduction in friction and wear when compared to the base oil. A recently developed advanced statistical method for ANOVA is utilized to analyze wear data for the first time in nano-lubrication studies and the results are consistent with the experimental trends. These TiO2 based nano-additives can be considered as promising anti-friction and anti-wear additives and help researchers to explore new materials and statistical methods for achieving the UN sustainability goals and thereby reducing the global energy consumption.