The synthesis of chiral molecules plays a fundamental role in contemporary organic chemistry, offering versatile applications across various fields, from pharmaceuticals to materials science.1,2 Within this domain, transition metal-catalyzed enantioselective C–H activation has emerged as a powerful strategy for accessing enantioenriched compounds with high efficiency and selectivity.3,4 While palladium, rhodium, and iridium metal have traditionally been the primary catalysts in this area, the increasing interest in sustainability and cost-effectiveness has prompted exploration into alternative transition metal catalysts where ruthenium and cobalt received significant attention.5,6 In this seminar, blueprints and advances in asymmetric synthesis via C–H activation utilizing ruthenium- and cobalt-based catalysts will be discussed. Subsequently, a research proposal will be presented for future work.

References:

1) Carriera, E. M.; Yamamoto, H. Comprehensive Chirality 2012
2) Colobert, F.; Wencel-Delord, J. C-H Activation for Asymmetric Synthesis 2019, 10.1002/9783527810857
3) Newton, C. G.; Wang, S. G.; Oliveira, C. C.; Cramer, N. Chem. Rev. 2017, 117, 8908.
4) Achar, T. K.; Maiti, S.; Jana, S.; Maiti, D. ACS Catal. 2020, 10, 13748.
5) Zheng, Y.; Zheng, C.; Qing, Gu.; You, S. L. Chem. Catalysis 2022, 2, 2965
6) Liang, H.; Wang, J. Chem. Eur. J. 2023, 29, e202202461