For a majority of people, work constitutes the central life interest. It seems like we are constantly told to pursue work that we are passionate about because of the widely held notion that people’s life can be most worth living in the presence of passion. In the workplace, passion is a highly sought-after, yet poorly understood, worker attribute. Pursuing one’s passion offers a host of benefits, but can also arouse negative emotions, lead to inflexible persistence, and interfere with achieving a balanced, successful life. Work and family are particularly important life domains in an employed adult’s life, wherein, the participation in the work domain influences and gets influenced by the participation in the family domain. Drawing on Conservation of Resources theory and Self Determination theory, we propose to examine the relationship between work passion and work-life interface through generation of psychological capital and self-regulation failure. We also propose to explore the role of cultural dimensions in the work passion-work life interface relationship, as reactions of work and family interface differ among people across cultures.