Drug delivery systems (DDSs) can improve the ADMET profiles of pharmaceutical agents and are becoming inevitable during drug development. They can be designed based on polymers, lipids or metallo-organic frameworks. Biocompatibility, good drug-loading/release profiles and option for site-directed drug-delivery are the desired characteristics during the development of new DDSs. Depending upon the nature of chemical component used, different types of aggregates such as liposomes, microspheres, transferosomes, ethosomes, archeosomes, niosomes, cubosomes etc. are possible. In the case of lipids, the nature of hydrophilic and lipophilic parts and their relative orientation have tremendous influence on
the nature of supramolecular structures and their drug delivery potential. Since synthetic chemistry offers the possibility of fine-tuning the chemical structure, there is high scope for
the design of new lipids for applications in this area. Biocompatibility, and option to do structure-property optimization in a modular fashion will be advatageous. In this respect, the
oxanorbornane-class of amphiphiles being developed in our laboratory offer great opportunities in drug delivery area. The initial part of this presentation will include the basic
aspects of drug delivery systems with emphasis on those involving lipids. Structural parameters which influence the supramolecular assembly and drug delivery properties will
also be discussed in detail. Subsequently, the proposed doctoral work will be presented,
which focuses on the synthesis of new oxanorbornane-based lipids with ionic head groups,
and different orientations of the lipophilic chains. Their applications in areas like transdermal
drug delivery based on our ongoing studies will also be discussed.

References:
1. Anthony. A., Attama., Mumuni. A. M., Recent Advances in Novel Drug Carrier Systems,
2012, 5, 109-140.
2. Hina. S., Rajni. B., Sandeep. A., Journal of Pharmaceutics, 2014, 1-10
3. Janni. D. S., Reddy. U.C., Saroj. S., Muraleedharan. K. M., Journal of Material Chemistry B,
2016, 4, 8025.
4. Som I, Bhatia K, M., Journal of Pharmacy and Bioallied Science, 2012, 4, 2-9.
5. Raichur. V., Kusum D., Drug Delivery, 2016, 23(1), 21–29.
6. Peipei. G., Yi. L., Jianping. Q., Mengmeng. N., Lian., Fuqiang H., Wei W., International
Journal of Nanomedicine 2011, 6, 965–974.