Micro particles with core-shell morphology have important medicinal
applications. This structure influences the drug release profile in the
body and provides other necessary features such as improved physical and
chemical stability, better appearance etc. These requirements are primarily
influenced by the size, size distribution and chemical composition of the
core-shell micro particles. This work experimentally investigates the best
production methods for micro encapsulation or generation of core-shell
micro-particles of metformin. The study identifies use of microfluidic
devices as the best method for generating micro encapsulated particles of
metformin. Consistency in particle production process using microfluidic
devices will be established and the mechanisms of droplet formation in
these microfluidic devices will be studied both experimentally and
analytically. In parallel, spinning disk and air atomization methods used
in the production of core particles of metformin will be analysed by
experimental and analytical methods.