Asymmetric transformations are essential to construct basic chiral skeletons of useful
compounds such as medicines and pesticides.1 Most catalytic asymmetric synthesis requires
metal-based homogeneous and heterogeneous catalysts,2 which are having their own merits
and demerits.3 Therefore, it is important to develop highly reactive, selective, recoverable and
reusable catalysts which has the advantageous of both homogeneous and heterogeneous
catalysts. This research proposal seminar will be focusing on the synthesis of new chiral metal
nanocatalysts and their applications for various asymmetric synthesis (Scheme 1). Chiral metal
nanocatalysts show high reactivity and they are easily reusable, compared to their
corresponding chiral homogeneous and heterogeneous metal catalysts.
Scheme 1. Asymmetric transformations using chiral metal nanocatalysts.
References:
1) Mao, Z.; Si, M..; Liu, Y.; Dong., H.; Wei, B.; Lin, G. J. Org. Chem. 2016, 81, 9903−9911.
2) (a) Ding, K. IUPAC, Pure Appl. Chem. 2006, 78, 239-301. (b) Hayashi, T.; Kumada, M. Acc. Chem. Res.
1982,15, 395-401.
3) (a) Bogdanovic, B.; Henc, B.; Losler, A.; Meister, B.; Pauling, H.; Wilke, G. Angew. Chem. Int. Ed. 1973,
12, 954 – 964. (b) Heitbaum, M.; Glorius, F.; Escher, I. Angew. Chem. Int. Ed. 2006, 45, 4732 – 4762.