The production of chiral drugs as their single enantiomer is highly required for the chemical industries.1 In this context, enantioselective functionalization of C–H bonds offers a powerful and transformative tool for the construction of complex chiral molecules in a step and atom-economical way. However, over a period, this area was dominated by 4d and 5d transition metal catalysts, such as palladium, rhodium, iridium and ruthenium, which are not only cost-intensive but are generally toxic which limits their application in agrochemical and pharmaceutical industries.2 As a direct result, earth-abundant and inexpensive 3d transition metal catalysts have recently attracted much attention in the area of C–H bond functionalization reactions. Among all 3d metals, cobalt complexes have emerged as versatile and efficient catalysts in C–H bond activation due to its unique reactivity. Therefore, great attention has been devoted to this field in recent years.3 In this seminar, a comprehensive overview of major development in enantioselective cobalt-catalysed C-H bond functionalization reactions will be discussed. In the end, our hypothesis and research proposal will be presented.

References:
1. Calcaterra. A, Acquarica. I, J. Pharm. Biomed. Anal. 2018, 147, 323– 340.
2. Mas-Roselll. J, Herraiz. A, Audic. B, Laverny. A, Cramer. N, Angew. Chem. Int. Ed. 2021, 60, 13198 – 13224.
3. Xu. W, Ye. M, Synthesis, 2022, 54, 4773–4783