Human beings co-evolved with plethora of microorganisms on its external as well as internal body cavity surfaces called microbiota or microflora. On the basis of relative abundance of these microflorae in the human gut, humans are stratified into three major groups namely Type-I (Bacteroides), Type-II (Prevotella) and Type-III (Ruminococcus). Microbiota feeds on prebiotics and produces a variety of metabolites which in many ways affect an individual’s physiological and pathophysiological conditions. Short Chain Fatty Acids (2-6 Carbon backbone), are one group of these metabolites, are extensively researched for their beneficial effect on the health including Neuropathological conditions like Autism spectral disease, Parkinson’s Disease, Alzheimer’s disease and many other psycho-physiological conditions. Many of the neurophysiological conditions arises due to channelopathies affecting the ion channels kinetics. Acid Sensing Ion channels are voltage independent ion channels belongs to the subfamily of ENac (Epithelial Sodium ion channels) and involved in stroke, seizures and other neurodegenerative disease although contradictory results exist. Our work is focusing on how these short chain fatty acids in any way modulates the activity of Acid sensing ion channels.