Demand for hydrogen is ever increasing and environmental legislations require that a major part of this is “green hydrogen”. Waste water streams from, e.g., food industries or bio refineries have aqueous effluents that contain dissolved organics, usually in the range of 5-20 wt%. Aqueous Phase Reforming (APR, Gasification in hot compressed water), allows for the generation of hydrogen from these, e.g., sugars. During APR, steam reforming of dissolved oxygenates occur at milder temperatures in pressurized liquid water (225-270°C, 30-60 bar). As these conditions also favour the Water Gas Shift reaction, hydrogen yields are maximized during APR. In general, hydrogen selectivity due to the competing formation of alkanes is one problem. Catalyst (typically metals on oxide support) stability under these harsh conditions is another issue for commercialization of the process. They relate to sintering of metal particles, leaching of the metal, support (and subsequent migration to cover metal particles as seen on the figure right) and/or coke formation due to oligomerisation of the intermediates formed during reaction, e.g., olefins, aldehydes, etc. Extensive research work carried out at our laboratories have allowed us to develop stable metal particles and supports that are suitable for APR catalysis. In this presentation I will discuss the reasons for the problems that affect the performance of the catalyst during APR of oxygenates found in bio waste streams. A thorough understanding of processes happening on the catalyst surface allows ways to overcome these limitations. Genesis of a catalyst that maximizes hydrogen yields and at the same time shows resistance to deactivation will be presented.