Post-translational modifications (PTMs) on histone and reader proteins are pivotal in Plasmodium falciparum pathogenesis, influencing chromatin structure and gene expression. These modifications, including acetylation, methylation, phosphorylation, and sumoylation, impact parasite development and virulence. Epigenetic reader proteins recognize specific PTMs, orchestrating downstream effects like effector protein recruitment and chromatin modulation, thus affecting gene regulation and pathogenesis. Understanding PTM-reader protein interplay offers insights into malaria's molecular mechanisms, potentially guiding novel therapeutic strategies. Despite their significance, only a few epigenetic reader proteins, such as bromodomain and chromodomain, have been functionally characterized in P. falciparum. Additionally, the roles of Tudor domain (reader) proteins encoded by the malaria parasite remain unknown. Investigating Tudor domains could unveil their involvement in malaria pathogenesis, constituting the focus of forthcoming research efforts.