Nucleic acids play crucial roles in various fields, such as gene cloning, gene therapy, diagnostics, and mRNA-based vaccinations, yet their stability at room temperature poses significant challenges. Traditional cold storage methods are often cost-ineffective and result in sample loss. Ionic Liquids (ILs) are a promising class of green solvents that have tunable physicochemical properties. We aim to investigate the potential of biocompatible ILs to stabilize nucleic acids, DNA and RNA, at ambient conditions. The proposed methodology involves synthesizing and characterizing biocompatible ILs, testing their efficacy in preserving DNA and RNA, and unraveling the underlying mechanisms through molecular dynamics simulations. The long-term goal is to identify specific IL compositions capable of preserving nucleic acids for extended periods at room temperature, potentially changing the current methodologies for nucleic acid storage and eliminating the need for expensive cold chains.