The floors and roofs of reinforced concrete (RC) buildings are made of integrally connected slabs and beams supported on columns. The drawback of the conventional beam-slab system is high self-weight, and the concrete consumed in the slab is more. The advantages of the voided slab system are up to 30% reduction in self-weight, longer-span slabs, and reduced cement consumption. However, there are no codal provisions available to implement such methods. The study aims to predict the punching shear and flexural capacity of the beam-voided slab systems numerically and experimentally. The developed beam-slab model was validated with prior experimental work in the literature. Later, a numerical study examined the flexural and shear behaviour of the two-way beam voided slab system. The analysis was conducted in two series; each series has three models: cuboid voided (CV) slab-beam model, sphere voided (S180V) slab-beam model, and control model with no voids. Deflection distribution, deflection contour, load sharing ratio, and load–deflection curves for the mid-span of the beam and slab of the beam-slab models are compared. The flexural and shear behaviour of the two-way beam voided slab system was examined in an experimental investigation, and the outcomes were contrasted with the control model. The punching shear capacity of the tested sphere voided specimen is 20 % less than the IS 456 (2000) methodology. The flexural capacity of beam-sphere void slab systems is 10 % higher than that of the control model. At last, a parametric analysis was carried out by considering variations in span length and various cuboid void configurations. Numerical findings of the parametric investigation are presented.