N and O-Heterocyclic compounds are found in manybiologically important natural products, drug molecules, and agrochemicals.1Development of elegant strategies for the synthesis of N and O-heterocyclic moleculeshave been a one of the active areas of research in contemporary organic synthesis. Particularly, metal carbenoid and carbene species, which undergoes many transformations like cyclopropanation, 1,2-insertion and ylide formationandare originally viewed as too reactive to be used for complex molecule synthesis,2are promising intermediates have recently surfaced for the synthesis of highly functionalized heterocyclic molecules.3 In this context, we have developed method for the trapping of in-situ generation of O and N-ylides from the metal carbenoids with simple and functionalized alkenes. These methods offer access to 2,2,3-trisubstituted dihydrobenzofurans and multisubstituted tetrahydrofurans, benzoxazepine, indoline and dihydropyridine based on the choice of coupling partners.4The details on this study will be discussed in this colloquium.

References:
1 Quin, L. D.; Tyrell, J. Fundamentals of Heterocyclic Chemistry: Importance in Nature and in the Synthesis of Pharmaceuticals; John Wiley & Sons Inc.: New York, 2010.
2 Xiao, Q.; Zhang, Y.; Wang, J.Acc. Chem. Res.2013, 46, 236.
3 a) Guo, X.; Hu, W. Acc. Chem. Res.2013, 46, 2427. b) Beckwith, R. E. J.; Davies H. M. L.Chem. Rev. 2003, 103, 2861.
4 Reddy, P. M.;Ramachandran,K..; Anbarasan,P. J. Catal.2021, 396, 291.